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KMID : 1225720230150010055
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Allergy, Asthma & Immunology Research : AAIR
2023 Volume.15 No. 1 p.55 ~ p.66
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Atopic Disorders and Their Risks of Migraine: A Nationwide Population-Based Cohort Study
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Han Ju-Hee
Lee Hyun-Ji
Yook Hwa-Jung
Han Kyung-Do
Lee Jee-Hyun
Park Young-Min
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Abstract
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Purpose : Migraine is a relatively common neurologic disorder. A possible link between atopic disorders and migraine has been suggested. This study investigated atopic disorders and their risks of migraine in the Korean population.
Methods : From the Korean National Health Insurance Service database, patients aged ≥ 20 years who underwent health screening between January and December of 2009 were enrolled. To evaluate the risk of migraine, Cox proportional hazards regression analyses were performed.
Results : In multivariable analysis, the atopic dermatitis group (adjusted hazard ratio [aHR], 1.28; 95% confidence interval [CI], 1.23?1.33), asthma group (aHR, 1.32; 95% CI, 1.30?1.34) and allergic rhinitis group (aHR, 1.45; 95% CI, 1.44?1.46) had significantly increased risks of migraine compared to their respective control groups (P < 0.001). The patients with 1 (aHR, 1.43; 95% CI, 1.42?1.44), 2 (aHR, 1.50; 95% CI, 1.47?1.53), and 3 (aHR, 1.64; 95% CI, 1.43?1.88) atopic disorders had significantly increased risks of migraine compared to the control group (P < 0.001).
Conclusions : Our results demonstrate that patients with atopic disorders may have increased risk of migraine and that the larger the number of concomitant atopic disorders, the higher the risk of migraine.
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KEYWORD
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Epidemiology, atopic dermatitis, allergic rhinitis, asthma, migraine
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